.crispr-sequence-view{--base-width:25px;--dna-ink:#273842;--dna-line:#dbe3eb;--dna-guide:#207986;--dna-pam:#a3782e;--dna-cut:#b9543e;--dna-edit:#78509d;color:var(--dna-ink);font-family:inherit;min-width:0;background:white;border:1px solid var(--dna-line);border-radius:16px;overflow:hidden}
.crispr-sequence-header{display:flex;align-items:center;justify-content:space-between;gap:16px;padding:21px 24px 15px}.crispr-sequence-view h3{font-size:17px;line-height:1.4;margin:0;overflow-wrap:anywhere}.crispr-sequence-header p{font-size:13px;color:#52636f;margin:5px 0 0;line-height:1.5;font-variant-numeric:tabular-nums}.crispr-window-controls{display:flex;align-items:center;gap:5px;flex:none}.crispr-sequence-view button{font:inherit;cursor:pointer;touch-action:manipulation}.crispr-window-controls button,.crispr-sequence-navigation button,.crispr-comparison-footer button{border:1px solid #c5d0dc;background:#fff;border-radius:7px;color:#344b5c;min-height:36px;min-width:36px;padding:6px 10px;font-size:13px;font-weight:550}.crispr-window-controls button:hover:not(:disabled),.crispr-sequence-navigation button:hover:not(:disabled),.crispr-comparison-footer button:hover:not(:disabled){background:#f1f4fa;border-color:#939fc3}.crispr-sequence-view button:disabled{background:#f3f5f7;color:#82909c;border-color:#e1e6ed;cursor:default;box-shadow:none}.crispr-window-controls>span:not(.crispr-control-separator){font-size:12px;min-width:42px;text-align:center;font-variant-numeric:tabular-nums}.crispr-control-separator{height:20px;width:1px;background:var(--dna-line);margin:0 5px}.crispr-sequence-view button:focus-visible,.crispr-sequence-view input:focus-visible,.crispr-sequence-scroll:focus-visible,.crispr-comparison-scroll:focus-visible{outline:3px solid #5556bb;outline-offset:2px}
.crispr-sequence-navigation{display:flex;justify-content:space-between;align-items:center;gap:12px;flex-wrap:wrap;padding:0 24px 17px}.crispr-sequence-navigation form{display:flex;align-items:center;gap:7px;margin:0}.crispr-sequence-navigation label{margin:0;font-size:12px;color:#52636f;font-weight:500}.crispr-sequence-navigation input{font:inherit;font-size:12px;border:1px solid #b9c5d1;border-radius:7px;min-height:36px;width:120px;padding:7px 9px;color:#273842;background:#fff}.crispr-sequence-navigation input::placeholder{color:#687986;opacity:1}.crispr-sequence-navigation>div{display:flex;gap:7px}.crispr-sequence-legend{display:flex;gap:13px 19px;flex-wrap:wrap;padding:13px 24px;border-top:1px solid var(--dna-line);background:#fafbfd;font-size:12px;line-height:1.5;color:#475c68}.crispr-sequence-legend>span{display:flex;align-items:center;gap:7px}.crispr-sequence-legend i{display:inline-block;width:11px;height:11px;border:1px solid;border-radius:3px}.legend-guide{border-color:var(--dna-guide)!important;background:#e3f2f3}.legend-pam{border-color:var(--dna-pam)!important;background:#fbefcf}.legend-cut{border-color:var(--dna-cut)!important;background:var(--dna-cut);width:2px!important;border-radius:0!important}.legend-edit{border-color:var(--dna-edit)!important;background:#eee6f5}
.crispr-selected-guide{display:flex;justify-content:space-between;align-items:start;gap:14px;padding:17px 24px 0;font-size:12px;line-height:1.6;color:#52636f}.crispr-selected-guide>div{min-width:0}.crispr-selected-guide strong{display:block;color:#225c69;font-size:14px;margin-bottom:3px;overflow-wrap:anywhere}.crispr-selected-guide>span{color:#92523f;flex-shrink:0}.crispr-guide-sequence{display:flex;align-items:center;gap:12px;flex-wrap:wrap;padding:8px 24px 0;font-size:12px;line-height:1.6;color:#52636f}.crispr-guide-sequence code{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;color:#254c58;font-size:13px;letter-spacing:1px;overflow-wrap:anywhere;word-break:break-all}.crispr-no-selection{font-size:13px;color:#52636f;padding:16px 24px 0;margin:0;line-height:1.6}
.crispr-reference-board{padding:17px 24px 0;min-width:0}.crispr-strand-key{display:flex;justify-content:space-between;gap:12px;font-size:11px;color:#52636f;line-height:1.5;margin-bottom:8px}.crispr-sequence-scroll,.crispr-comparison-scroll{overflow-x:auto;overscroll-behavior-x:contain;scrollbar-width:thin;padding:4px 3px 12px}.crispr-base-grid{width:calc(var(--base-count)*var(--base-width));min-width:100%;position:relative}.crispr-guide-tracks{display:grid;gap:5px;margin-bottom:6px}.crispr-guide-track{height:29px;position:relative}.crispr-guide-band{position:absolute;left:calc(var(--track-offset)*var(--base-width));width:calc(var(--track-span)*var(--base-width));height:28px;min-height:28px!important;display:flex;align-items:center;justify-content:center;gap:6px;overflow:hidden;white-space:nowrap;border:1px solid #a5bbc3;border-radius:6px;background:#f1f6f7;color:#355b69;font-size:11px!important;padding:3px 8px;font-weight:550}.crispr-guide-band span:last-child{overflow:hidden;text-overflow:ellipsis}.crispr-guide-band.is-selected{border-color:#3a8791;color:#185b66;background:#e7f4f4}.crispr-guide-band:hover{background:#dbecef}.crispr-position-row,.crispr-base-row,.crispr-bond-row{display:grid;grid-template-columns:repeat(var(--base-count),var(--base-width));justify-content:start}.crispr-position-row{height:24px;align-items:center}.crispr-position{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:9px;line-height:1;text-align:center;color:#62727e;overflow:visible;white-space:nowrap}.crispr-position:first-child{text-align:left}.crispr-position:last-child{text-align:right}.crispr-strand-pair{position:relative}.crispr-base-row{position:relative;z-index:1}.crispr-base{font-family:ui-monospace,SFMono-Regular,Menlo,monospace!important;font-size:15px!important;font-weight:600;line-height:1;min-height:35px!important;height:35px;border:1px solid #dbe4eb;border-radius:4px;background:#f5f8fa;color:#2a404b;padding:0!important;margin:0 1px;min-width:0!important;display:grid;place-items:center}.crispr-base:hover{border-color:#4a5d75;background:#eaf0f5}.crispr-base.is-guide{background:#e8f4f5;border-color:#a5cbd0;color:#215b65}.crispr-base.is-pam{background:#faedc9;border-color:#b4934b;color:#72551f}.crispr-base.is-edit{box-shadow:inset 0 -3px #8b67ab}.crispr-bond-row{height:10px;align-items:stretch}.crispr-bond-row>span{margin:0 auto;width:2px;background:#bdcad2;opacity:.75}.crispr-cut-line{position:absolute;z-index:2;left:calc(var(--cut-offset)*var(--base-width) - 1px);top:-6px;bottom:-6px;border-left:2px dashed var(--dna-cut);pointer-events:none}.crispr-cut-line:before,.crispr-cut-line:after{content:'';position:absolute;left:-5px;width:8px;height:3px;background:var(--dna-cut);border-radius:2px}.crispr-cut-line:before{top:0}.crispr-cut-line:after{bottom:0}.crispr-sequence-inspection{background:#f8fafc;border-top:1px solid #e6ebf0;font-size:12px;line-height:1.6;min-height:49px;margin:0;padding:14px 24px;color:#425965}.crispr-track-note{font-size:11px;color:#63717d;line-height:1.6;margin:0;padding:0 24px 14px}
.crispr-edit-comparison{border-top:1px solid var(--dna-line);padding:21px 24px 18px}.crispr-edit-heading{display:flex;align-items:start;justify-content:space-between;gap:16px}.crispr-edit-heading h3{font-size:15px}.crispr-edit-heading p{font-size:13px;line-height:1.6;color:#4c5e6b;margin:5px 0 0}.crispr-edit-size{background:#f2edf8;border:1px solid #d9cbe7;padding:5px 9px;border-radius:7px;color:#674787;font-size:12px;line-height:1.5;white-space:nowrap}.crispr-comparison-note{font-size:12px;line-height:1.6;color:#64727d;margin:10px 0 15px}.crispr-diff-labels{display:flex;justify-content:space-between;font-size:11px;line-height:1.5;color:#52636f;margin-bottom:8px}.crispr-comparison-grid{width:max-content;min-width:100%;display:grid;gap:9px}.crispr-diff-row{display:flex;gap:2px;position:relative}.crispr-diff-base{display:inline-grid;place-items:center;font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:14px;font-weight:550;height:32px;min-width:23px;border:1px solid #dbe4eb;border-radius:4px;color:#30434f;background:#f5f8fa}.crispr-diff-base.is-removed{color:#9a4f3c;background:#fcece6;border-color:#dcb09f}.crispr-diff-base.is-added{color:#6c4290;background:#eee4f7;border-color:#b59ccd}.crispr-diff-base.is-gap{color:#65737e;background:#fff;border:1px dashed #bdc8d2}.crispr-comparison-footer{display:flex;justify-content:space-between;align-items:center;gap:12px;flex-wrap:wrap;margin-top:11px;font-size:11px;color:#5c6e7b;line-height:1.6}.crispr-comparison-footer>div{display:flex;gap:5px}.crispr-comparison-footer button{font-size:11px;min-height:32px;min-width:32px;padding:5px 8px}.crispr-sequence-empty{padding:26px}.crispr-sequence-empty p{font-size:14px;line-height:1.6;margin:9px 0 0;color:#546572}
@media(max-width:650px){.crispr-sequence-header{padding:18px 16px 13px;align-items:flex-start;flex-direction:column;gap:12px}.crispr-sequence-header h3{font-size:16px}.crispr-window-controls{width:100%;justify-content:flex-end}.crispr-window-controls button:nth-child(2){margin-right:auto}.crispr-sequence-navigation{padding:0 16px 14px;gap:10px}.crispr-sequence-navigation>div{width:100%}.crispr-sequence-navigation>div button{flex:1}.crispr-sequence-navigation input{width:120px}.crispr-sequence-legend{padding:12px 16px;gap:9px 14px}.crispr-selected-guide{padding:15px 16px 0;display:block}.crispr-selected-guide>span{display:block;margin-top:8px}.crispr-guide-sequence{padding:8px 16px 0;gap:3px 9px}.crispr-reference-board{padding:16px 13px 0}.crispr-strand-key{font-size:10px}.crispr-sequence-inspection{padding:13px 16px;font-size:11px}.crispr-no-selection{padding:15px 16px 0}.crispr-track-note{padding:0 16px 13px}.crispr-edit-comparison{padding:18px 16px}.crispr-edit-heading{gap:10px}.crispr-edit-heading p{font-size:12px}.crispr-comparison-note{font-size:11px}.crispr-comparison-footer{font-size:10px}.crispr-comparison-footer>div{margin-left:auto}}